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Why would our hair turn grey and is this process reversible?

Updated: Mar 29, 2020

Most of us find our first “greys” by the time we turn 30, usually at the temples, then later, across the scalp.  The grey hair “rule of thumb” is that by the age of 50, half of the population have lost the color in 50% of their hair. When researchers tested this rule, they found that 74% of people aged between 45 and 65 had grey hair, with an average intensity of 27%.

Hair color is produced by cells known as melanocytes, which migrate into the hair bulb as the hair follicles develop in utero. The melanocytes produce pigment that is incorporated into the growing hair fibers to produce hair in a bewildering array of natural shades.

Hair color depends on the presence and ratios of two groups of melanin types: eumelanin (brown and black pigments) and pheomelanin (red and yellow pigments). While variations in the ratio of these pigments can produce a large number of colors and tones, this explains the variety of natural hair color.

So, what happens when our hair turns grey and why doesn’t pigment production turn back on?

At the end of each hair cycle, some pigment-producing melanocytes become damaged and die. If the melanocyte stem cell reservoir at the top of the hair follicle can replenish the bulb, this keeps pigment production going. But when the reservoir of stem cells is exhausted, pigment production stops and the hair turn grey. In order to prevent hair from going grey, it would need to either prolong the life of the melanocytes in the hair bulb – by protecting them from injury – or expand the melanocyte stem cell reservoir in the upper or top region of the hair follicle so they continue to replace lost pigment cells.

Toulison Nutraceuticals Inc. has identified a series of plant-derived compounds that protect hair follicle melanocytes from damage at the end of the hair cycle. This enables pigment production to restart as soon as the next hair cycle begins.

The compounds work by mimicking the action of an enzyme called DOPA-chrome tautomerize. This enzyme is the naturally occurring antioxidant in the hair bulb that protects melanocytes from oxidative damage. By duplicating the effects of DOPA-chrome tautomerize, melanocyte metabolism and survival improves.

The new agents are being formulated into a product, called Hair Growth Enhancer, which can be applied as a spray-on hair root. This product will not re-color grey hair or bring back the dead cells that produce hair color but will protect your melanocytes. The newly developed Hair Growth Enhancer not only reverses the hair color but also reduces the hair loss, improves the hair look and thickens the hair strands due to increased keratin production.

Below we present our data about an incredibly beneficial effect of our Hair Growth Enhancer on hair. In our experiments, this product significantly increased the hair thickness up to size of regular colored hair (Fig.1,2). After treatment with Hair Growth Enhancer, the grey hair increased the same thickness as regular colored hair.

Fig. 1

Fig. 2

Due of the capacity of melanin (both eumelanin and pheomelanin) to provide autofluorescence, we took fluorescent microcopy images for untreated grey hair, grey hair treated with our product (for 4 weeks) and regular colored hair to witness any differences in levels of melanin production. On a picture below, you can see an increase in intensity of fluorescence (which means an increase of melanin production) in grey hair treated with the Hair Growth Enhancer in comparison with untreated grey hair.

We invite you to try our magnificent Hair Growth Enhancer to experience lots of benefits in order to have naturally beautiful and healthy hair. Please, visit our website to order this product on-line and get introduced to a variety of different other products our company offers to its customers at

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